Jesse gives another update on his health situation from back in Nashville, revealing that he'll be starting up a podcast of his own titled Jesse Vs. Cancer in the near future, before Matt and Andy welcome pride of New Orleans Sean Patton (@mrseanpatton) to the show to talk about the payoff of the daffodil tea bit from last week, Sean's mom dressing as a hipster for Halloween, the normcore movement, Sean's underage Jesse memories, trucker hats, the fake black lady in Spokane, Roderick on the Line's excellent take on out-underdogging, Sean's science TV show, testing bacteria in surfer asses, the Point Break remake, Hans Rosling's different angle on overpopulation, immaculate conception among sawfish, Crocodile Dundee III, Sean assuming friend of the show Mark Agee was gay, wheelchair comedy, putting kill switches in genetically modified organisms, what baby traits you should be allowed to edit, where to get real New Orleans food in LA and the middle class of comedy.